December 14th, 2006

Dear Colleague,

We'd like to draw your attention to an open-access research article, entitled Palladin Mutation Causes Familial Pancreatic Cancer and Suggests a New Cancer Mechanism by Teresa Brentnall and colleagues.

The Study

The researchers found a germline mutation in the palladin gene in a large kindred with familial pancreatic cancer. Cells expressing the mutant form of palladin have greater ability to migrate. Palladin, which encodes a cytoskeletal protein, is also overexpressed in sporadic pancreatic tumors. The results strongly suggest that alterations in palladin play a role in familial and sporadic pancreatic cancer.

PLoS Medicine

PLoS Medicine is a peer-reviewed, international, open-access journal that publishes important original research and analysis relevant to human health.

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With best regards,
The PLoS Medicine Editors

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