We are pleased to bring you an early "sneak-preview" research article and related commentary that showcase the broad-reaching content that will be featured in PLoS Neglected Tropical Diseases. All PLoS content is freely available online for you to use and share in any way you choose, and the copyright remains where it belongs—with the author.
Research Article: Genetic Selection of Low Fertile Onchocerca volvulus by Ivermectin Treatment by Roger Prichard et al. Researchers studied genetic changes in Onchocerca volvulus following exposure to ivermectin, the primary treatment for onchocerciasis (river blindness). This article shows that long-term treatment selects for the heterozygotic form of β-tubulin, a gene linked to ivermectin resistance.
Expert Commentary: Ivermectin Resistance in Onchocerca volvulus—Toward a Genetic Basis by Sara Lustigman and James McCarter. Two leading experts set the above-mentioned research article in context, explaining the background to the study, its strengths and limitations, and the importance of these findings to onchocerciasis control programs.
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