PLoS Biology: A Peer-Reviewed Open Access Journal Published by the Public Library of Science

Dear Colleague,

We'd like to draw your attention to a series of studies on pancreatic β cell biology recently published in PLoS Biology. Please feel free to read, share, print, and use these articles anyway you wish at no charge—thanks to the reality of open-access publishing.

The Studies

  1. Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells by Leonard Guarente and colleagues
    This study shows that Sirt1 regulates the expression of the metabolic decoupling gene UCP2 in pancreatic β cells, highlighting a possible role for Sirt1 in coordinating insulin release in response to changing dietary conditions. Read the Synopsis. (This feature encapsulates the essence of the research in accessible language and explains the significance of the work within a broad context).
  2. Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus by Seung Kim and colleagues
    TGF-β signaling is known to regulate the development of pancreatic β cells; here the authors show that TGF-β is also required for the maintenance of β cell identity in the adult. Read the Synopsis.
  3. Critical Role of Gap Junction Coupled KATP Channel Activity for Regulated Insulin Secretion by David Piston and colleagues
    This study finds that gap junctions electrically couple pancreatic β cells and can preserve excitability (glucose sensitivity and insulin secretion) in the islet even when a majority of cells have nonfunctional ATP-activated potassium channels. Read the Synopsis.

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We welcome you to PLoS Biology.

Caitlin Sedwick
Associate Editor, PLoS Biology